The Gastrea virus quickly spread as infected hosts gained new powers and abilities with each rapid mutation even while attacking, killing, and infecting multiple new hosts. Unable to fight such a pandemic, the remaining humans retreated into cities surrounded by giant monoliths made of Varanium, one of the few materials that can stop the Gastrea. Now mankind's last hope is the Cursed Children, infected young girls who have retained their humanity. Paired with a human partner, they alone have the strength to combat a Gastrea, but their power makes them feared and shunned by most humans.